“no, they're not replacement for prescription stimulants. The reality is that stimulants are extremely effective”
Methylphenidate or amphetamine?
“If you have ADHD, there's a good chance you've tried either methylphenidate or an amphetamine, but they actually work pretty differently.”
My ranking: #1 Dexedrine, #2 methylphenidate, #3 Adderall.
“Number one is [Dexedrine], and it's not particularly close.”
Methylphenidate is “slightly less effective, particularly for motivation and task initiation, but potentially more sustainable from a tolerability standpoint”. And in the end:
“The best ADHD medication is ultimately the one you respond to and tolerate the best.”
What I'd add on top
“ADHD isn't just about struggling to focus. What about memory, mood, and stimulant tolerance?”
- Tropisetron: “Number 1 is [Tropisetron], which absolutely changed the game for me.”
- TAK-653: processing speed. “This is absolutely one of my favorites.”
- Bromantane: helps “significantly with stimulants especially when it comes to anxiety and mental fatigue”
- Nefiracetam for memory, NSI-189 for mood, 9-Me-BC for stimulant tolerance.